TY - JOUR T1 - Study of the in vitro activity of amoxicillin/clavulanic acid and other beta-lactam antibiotics against Escherichia coli isolated from urine specimens36706 JF - Acta Clin.Belg. Y1 - 2001 A1 - R. Vanhoof A1 - Carpentier,M. A1 - Delannoy,P. A1 - Fagnart,O. A1 - Lontie,M. A1 - Mans,I. A1 - Nyssen,H.J. A1 - Van Nimmen,L. KW - 0 KW - a KW - acid KW - Activity KW - Agent KW - Agents KW - Amoxicillin-Potassium Clavulanate Combination KW - Ampicillin KW - Ampicillin Resistance KW - Animals KW - Anti-Bacterial Agents KW - Antibiotic KW - antibiotics KW - article KW - Belgium KW - beta-Lactam Resistance KW - Combination KW - community KW - Community-Acquired Infections KW - Comparative Study KW - criteria KW - Cross Infection KW - distribution KW - drug effects KW - epidemiology KW - Escherichia coli KW - Escherichia coli Infections KW - general KW - hospital KW - Humans KW - im KW - IS KW - isolation & purification KW - journal KW - Laboratories KW - Microbial Sensitivity Tests KW - microbiology KW - nosocomial KW - Patient KW - patients KW - pharmacology KW - POPULATION KW - Print KW - RATES KW - resistance KW - SB - IM KW - statistics & numerical data KW - study KW - Technique KW - Urinary KW - urine AB - A total of 205 serial, unduplicated urinary isolates of Escherichia coli was collected from June through August 1998 in 2 community and 3 hospital laboratories. By using the NCCLS broth microdilution technique, their in vitro susceptibility to ampicillin, amoxicillin/clavulanic acid, cefuroxime, cefuroxime axetil, ticarcillin/clavulanic acid and piperacillin/tazobactam was determined. One hundred and twenty isolates were from hospitalised patients, 85 from ambulatory, 129 community acquired and 76 nosocomial. Half of the nosocomial isolates were obtained from naturally produced and half from alternatively produced urine specimens. In general, the highest susceptibility rates, following NCCLS criteria, were found for piperacillin/tazobactam (93.2%) followed by cefuroxime (92.2%) and amoxicillin/clavulanic acid (82.9%). Ampicillin showed a clear bimodal distribution with a clear peak for the resistant population. The highest degree of ampicillin resistance was found in nosocomial isolates. Overall, ampicillin showed the lowest degree of susceptibility. Most of the ampicillin resistant isolates remained susceptible to piperacillin/tazobactam, cefuroxime and amoxicillin/clavulanic acid. In general, the community acquired isolates had higher susceptibility rates than the nosocomial isolates VL - 56 CP - 1 U1 - 38449 ER -