TY - JOUR T1 - Genotoxicity testing of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke with germination inhibitory activity. JF - Mutat Res Genet Toxicol Environ Mutagen Y1 - 2015 A1 - Light, Marnie E A1 - Anthonissen, Roel A1 - Annemarie Maes A1 - Luc Verschaeve A1 - Pošta, Martin A1 - Van Staden, Johannes KW - 4-Nitroquinoline-1-oxide KW - Benzopyrenes KW - Cell Line, Tumor KW - Cell Survival KW - Furans KW - Genes, Reporter KW - Germination KW - Hepatocytes KW - Humans KW - Luciferases KW - Mutagenicity Tests KW - Mutagens KW - Plants KW - Quinolones KW - Salmonella typhimurium KW - Seeds KW - SOS Response (Genetics) KW - Transcription Factors AB -

Plant-derived smoke and certain smoke compounds improve seed germination and enhance seedling growth of many species. Thus, smoke-infused water and the active smoke-derived compounds have the potential to be used in different agricultural and horticultural applications. However, despite these interesting and potentially practical properties, it should also be ascertained whether such compounds may pose a health risk, particularly if they are to be used in the production of food or fodder crops. Amongst some of the aspects that would be important to understand are any possible genotoxic properties that the compounds may possess due to potential carry-over effects. Here, we report on a genotoxicity study of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke previously shown to have germination inhibitory activity. Using two in vitro tests, namely the bacterial VITOTOX® test (with/without S9 metabolic activation) and the cytome assay on human C3A cells, no genotoxicity or toxicity was found. Furthermore, these results support a previous study where a related smoke-derived compound with germination promoting properties was investigated.

VL - 778 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25726142?dopt=Abstract M3 - 10.1016/j.mrgentox.2014.12.006 ER -