%0 Journal Article %J Clin.Chim.Acta %D 1981 %T Simultaneous determination of p-aminobenzoic acid, acetyl-p-aminobenzoic acid and p-aminohippuric acid in serum and urine by capillary gas chromatography with use of a nitrogen-phosphorus detector151 %A Libeer,J.C. %A S. Scharpe %A Verkerk,R.M. %A Deprettere,A.J. %A P. Schepens %K 0 %K 4-Aminobenzoic Acid %K a %K acid %K Acids %K Aminobenzoic Acids %K Aminohippuric Acids %K analogs & derivatives %K analysis %K article %K blood %K chromatography %K Chromatography,Gas %K derivatization %K detection %K function %K gas chromatography %K Humans %K im %K IS %K IT %K journal %K metabolites %K Nitrogen %K p-Aminohippuric Acid %K Phosphorus %K Print %K Sample %K Samples %K SB - IM %K SCREENING %K screening test %K serum %K small intestine %K study %K Synthetic %K Test %K tests %K urine %K use %X In various studies during recent years, the use of p-aminobenzoic acid has been described in screening tests for exocrine pancreatic function. A synthetic three-unit compound N-benzoyl-L-tyrosyl-p-aminobenzoic acid has been administered orally and hydrolysed in the small intestine in the presence of chymotrypsin to N-benzoyl-L-tyrosine and p-aminobenzoic acid. This study describes a convenient procedure in which, after a selective extraction and derivatization with diazomethane, capillary gas chromatography is used combined with nitrogen-sensitive detection. With the proposed procedure, p-aminobenzoic acid and its major metabolites, acetyl-p-aminobenzoic acid and p-aminohippuric acid, can be monitored in serum and in urine samples %B Clin.Chim.Acta %V 115 %P 119 - 123 %8 10/9/1981 %G eng %N 2 %1 151 %& 119