%0 Journal Article %J Acta Clin.Belg. %D 2005 %T High prevalence of penicillin resistance and comparative in vitro activity of various antibiotics in clinical isolates of streptococcus pneumoniae isolated in the Province of Hainaut during winter 200436750 %A R. Vanhoof %A Brouillard,J. %A Damee,S. %A d'Hondt,N. %A Haccourt,A. %A Mansoor,I. %A Marchal,J.F. %A Philippart,I. %A Trigaux,F. %A Van Bosterhaut,B. %A Rossi,C. %A Van Bossuyt,E. %K 2004 %K a %K Activity %K ADOLESCENT %K Adult %K Amoxicillin %K an %K Antibiotic %K antibiotics %K article %K AS %K Belgium %K Child %K Child,Preschool %K Ciprofloxacin %K Clinical %K Drug Resistance,Bacterial %K Erythromycin %K Follow %K High prevalence %K Humans %K im %K IS %K journal %K Microbial Sensitivity Tests %K middle aged %K ON %K Penicillin Resistance %K Phenotype %K Pilot Projects %K present %K prevalence %K Print %K r %K RATES %K recommendation %K Recommendations %K Research %K Research Support %K resistance %K SB - IM %K Streptococcus pneumoniae %K study %K Technique %K Tetracycline %K Winter %X A total of 154 isolates of Streptococcus pneumoniae obtained from 8 different centres in the province of Hainaut were included in this study. The susceptibilities to penicillin, amoxicillin, cefuroxime, ciprofloxacin, moxifloxacin, erythromycin and tetracycline were determined by a microdilution technique following NCCLS recommendations. Decreased susceptibility to penicillin was 32.5% (23.4% intermediate and 9.1% high-level). The other insusceptibility rates were as follows: amoxicillin 1.9% [0% Resistance (R)], cefuroxime 23.4% (R 22.1%), ciprofloxacin 9.1% (R 1.3%), erythromycin 39.6% (R 38.3%), and tetracycline 31.8% (R 30.5%). No decreased susceptibility was found for moxifloxacin. MICs of amoxicillin, cefuroxime, erythromycin and tetracycline rose with those of penicillin for penicillin-insusceptible isolates. Most penicillin-insusceptible isolates remained fully susceptible to amoxicillin (94%), while moxifloxacin and ciprofloxacin kept an activity on 100% and 92% of these isolates respectively. Phenotypes with triple or quadruple insusceptibility were present in 31.2% of the isolates. Penicillin-insusceptible isolates showed a co-insusceptibility of 36.7% to erythromycin, 30.0% to tetracycline and 3.3% to ciprofloxacin %B Acta Clin.Belg. %V 60 %P 345 - 349 %8 0/11/2005 %G eng %N 6 %1 38451 %& 345