<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kris Doggen</style></author><author><style face="normal" font="default" size="100%">Hilde Beele</style></author><author><style face="normal" font="default" size="100%">Kevin Deschamps</style></author><author><style face="normal" font="default" size="100%">Isabelle Dumont</style></author><author><style face="normal" font="default" size="100%">Astrid Lavens</style></author><author><style face="normal" font="default" size="100%">Viviane Van Casteren</style></author><author><style face="normal" font="default" size="100%">Giovanni Matricali</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Low prevalence of previous lower limb revascularisation in patients with diabetes and acute Charcot foot: results from a case-control study.</style></title><secondary-title><style face="normal" font="default" size="100%">7th International Symposium on the Diabetic Foot</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">charcot foot</style></keyword><keyword><style  face="normal" font="default" size="100%">diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">lower-limb revascularization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">International Working Group on the Diabetic Foot</style></publisher><pub-location><style face="normal" font="default" size="100%">The Hague, Netherlands</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim:&lt;/strong&gt; Charcot foot is a rare but devastating complication of diabetes, leading to uncontrolled inflammation and high risk of osteolysis in its acute phase. Preserved local perfusion is a hypothesized prerequisite for the detrimental inflammatory response. We sought support for this hypothesis by studying the prevalence of previous lower limb revascularisation (LLR), as a marker of peripheral macroangiopathy, in patients with diabetes and Charcot foot.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Methods:&lt;/strong&gt; Patients with diabetes and incident acute Charcot foot, but without a history of diabetic foot ulcers (DFU) (Charcot group, N=50) were retrospectively identified in a database used for quality of care monitoring in 36 Belgian specialized diabetic foot clinics in the period 2005-2011. [1] Patients without Charcot foot, but who had diabetic foot ulcers (DFU), served as controls (DFU group, N=3,147). Prevalence of previous LLR was compared between both groups using logistic regression.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; The Charcot group was significantly younger than the DFU group (59.1 vs. 69.1 years, P&amp;lt;0.001). Age-adjusted prevalence of previous LLR was significantly lower in the Charcot group than in the DFU group (3.5 vs. 29.8%, P&amp;lt;0.05), while the age-adjusted prevalence of coronary artery disease and stroke did not significantly differ (41.7 vs. 38.3%, P&amp;gt;0.05).&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; Charcot foot in diabetes only seems to occur in patients without a history of LLR. Despite the limitation of the cross-sectional nature of this study, our findings support the hypothesis that among patients with diabetes, Charcot foot occurs preferentially when lower limb perfusion is preserved.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;[1] Doggen K, Diabetes Metab Res Rev. 2014;30(5):435-43.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">International Working Group on the Diabetic Foot</style></issue><custom1><style face="normal" font="default" size="100%">1049</style></custom1><custom2><style face="normal" font="default" size="100%">20/05/2015</style></custom2></record></records></xml>