<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maertens, Kirsten</style></author><author><style face="normal" font="default" size="100%">Hoang, Thi Thu Ha</style></author><author><style face="normal" font="default" size="100%">Nguyen, Trung Dac</style></author><author><style face="normal" font="default" size="100%">Raïssa Nadège Caboré</style></author><author><style face="normal" font="default" size="100%">Duong, Thi Hong</style></author><author><style face="normal" font="default" size="100%">Huygen, Kris</style></author><author><style face="normal" font="default" size="100%">Hens, Niel</style></author><author><style face="normal" font="default" size="100%">Van Damme, Pierre</style></author><author><style face="normal" font="default" size="100%">Dang, Duc Anh</style></author><author><style face="normal" font="default" size="100%">Leuridan, Elke</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam.</style></title><secondary-title><style face="normal" font="default" size="100%">Clin Infect Dis</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Clin. Infect. Dis.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016 Dec 01</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">63</style></volume><pages><style face="normal" font="default" size="100%">S197-S204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt; Maternal vaccination with an acellular pertussis (aP)-containing vaccine is a recommended strategy in a growing number of industrialized countries, to protect young infants from disease. Little is known on the effect of this strategy in low- and middle-income countries. Following a previous report on the effect of adding a pertussis and diphtheria component to the tetanus vaccination program in pregnant women in Vietnam, we report on infant immune responses to a booster aP vaccine dose in this randomized controlled clinical trial.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt; Thirty infants of Tdap (tetanus, diphtheria, and acellular pertussis)-vaccinated pregnant women and 37 infants of women vaccinated with a tetanus-only vaccine received a fourth aP-containing vaccine dose in the second year of life. Blood was taken 1 month after the fourth infant dose. Immunoglobulin G (IgG) antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), tetanus toxoid (TT), and diphtheria toxoid (DT) were measured using commercially available enzyme-linked immunosorbent assays (ELISA).&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt; One month after the booster dose, significantly lower antibody titers were measured in the Tdap group for anti-TT IgG (P &lt; .001) only. Anti-DT IgG, anti-PT IgG, anti-Prn IgG, and anti-FHA IgG antibody titers were comparable for both groups. A rise in antibody concentrations was elicited for all (except DT) antigens after boosting.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt; The present results indicate that the blunting of infant pertussis responses induced by maternal immunization, measured after a primary series of aP vaccines, was resolved with the booster aP vaccine dose. These results add to the evidence for national and international decision makers on maternal immunization as a vaccination strategy for protection of young infants against infectious diseases.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">suppl 4</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/27838673?dopt=Abstract</style></custom1></record></records></xml>