<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Smit, G Suzanne A</style></author><author><style face="normal" font="default" size="100%">Steven Abrams</style></author><author><style face="normal" font="default" size="100%">Dorny, Pierre</style></author><author><style face="normal" font="default" size="100%">Speybroeck, Niko</style></author><author><style face="normal" font="default" size="100%">Brecht Devleesschauwer</style></author><author><style face="normal" font="default" size="100%">Veronik Hutse</style></author><author><style face="normal" font="default" size="100%">Hilde Jansens</style></author><author><style face="normal" font="default" size="100%">Heidi Theeten</style></author><author><style face="normal" font="default" size="100%">Beutels, Philippe</style></author><author><style face="normal" font="default" size="100%">Hens, Niel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006: a comparative analysis with hepatitis A virus seroprevalence</style></title><secondary-title><style face="normal" font="default" size="100%">Epidemiol Infect</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytomegalovirus</style></keyword><keyword><style  face="normal" font="default" size="100%">estimating age and birth cohort-specific seroprevalence</style></keyword><keyword><style  face="normal" font="default" size="100%">hepatitis A virus</style></keyword><keyword><style  face="normal" font="default" size="100%">mixture modelling</style></keyword><keyword><style  face="normal" font="default" size="100%">seroincidence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Jan</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">147</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31-34%) in 2002 and 31% (95% CI 30-32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.&lt;/p&gt;
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