<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Desombere</style></author><author><style face="normal" font="default" size="100%">Freya Van Houtte</style></author><author><style face="normal" font="default" size="100%">Philip Meuleman</style></author><author><style face="normal" font="default" size="100%">Geert Leroux-Roels</style></author></authors><tertiary-authors><author><style face="normal" font="default" size="100%">Van Vlierberghe, Hans</style></author><author><style face="normal" font="default" size="100%">André Elewaut</style></author></tertiary-authors><subsidiary-authors><author><style face="normal" font="default" size="100%">Ali Farhoudi</style></author><author><style face="normal" font="default" size="100%">Lieven Verhoye</style></author><author><style face="normal" font="default" size="100%">Caroline Buysschaert</style></author><author><style face="normal" font="default" size="100%">Yvonne Gijbels</style></author><author><style face="normal" font="default" size="100%">Sibyl Couvent</style></author><author><style face="normal" font="default" size="100%">Wilfried Swinnen</style></author><author><style face="normal" font="default" size="100%">Andrea Magri</style></author><author><style face="normal" font="default" size="100%">Zania Stamataki</style></author><author><style face="normal" font="default" size="100%">Jane A McKeating</style></author></subsidiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">A Role for B Cells to Transmit Hepatitis C Virus Infection.</style></title><secondary-title><style face="normal" font="default" size="100%">Front Immunol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibodies, Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">B-Lymphocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Broadly Neutralizing Antibodies</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Models, Animal</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepacivirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis C</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver Transplantation</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">mice</style></keyword><keyword><style  face="normal" font="default" size="100%">middle aged</style></keyword><keyword><style  face="normal" font="default" size="100%">serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Transplantation Chimera</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaccine Development</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Envelope Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Hepatitis Vaccines</style></keyword><keyword><style  face="normal" font="default" size="100%">Young adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Hepatitis C virus (HCV) is highly variable and transmits through infected blood to establish a chronic liver infection in the majority of patients. Our knowledge on the infectivity of clinical HCV strains is hampered by the lack of cell culture systems that support efficient viral replication. We and others have reported that HCV can associate with and infect immune cells and may thereby evade host immune surveillance and elimination. To evaluate whether B cells play a role in HCV transmission, we assessed the ability of B cells and sera from recent (&amp;lt;2 years) or chronic (≥ 2 years) HCV patients to infect humanized liver chimeric mice. HCV was transmitted by B cells from chronic infected patients whereas the sera were non-infectious. In contrast, B cells from recently infected patients failed to transmit HCV to the mice, whereas all serum samples were infectious. We observed an association between circulating anti-glycoprotein E1E2 antibodies and B cell HCV transmission. Taken together, our studies provide evidence for HCV transmission by B cells, findings that have clinical implications for prophylactic and therapeutic antibody-based vaccine design.&lt;/p&gt;
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