Pre-exposure intradermal rabies vaccination: a non-inferiority trial in healthy adults on shortening the vaccination schedule from 28 to 7 days.

Last updated on 23-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article





Background: The existing four-week pre-exposure rabies vaccination schedule is costly and often not practicable. Shorter effective schedules would result in wider acceptance. Methods: We conducted a non-inferiority trial in 500 healthy adults comparing the safety and immunogenicity of a two-visit (day 0 and day 7) intradermal (ID) primary vaccination (two doses of 0.1 ml ID of the human diploid cell culture rabies vaccine (HDCV) at day 0 and 7) versus a standard three-visit schedule (single dose of 0.1 mL ID at day 0, 7, and 28). One to three years after primary vaccination, a single boo…

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