Systematic identification of hypothetical bacteriophage proteins targeting key protein complexes of pseudomonas aeruginosa

Last updated on 23-8-2019 by Anonymous (non vérifié)

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Peer reviewed scientific article



Addressing the functionality of predicted genes remains an enormous challenge in the postgenomic era. A prime example of genes lacking functional assignments are the poorly conserved, early expressed genes of lytic bacteriophages, whose products are involved in the subversion of the host metabolism. In this study, we focused on the composition of important macromolecular complexes of Pseudomonas aeruginosa involved in transcription, DNA replication, fatty acid biosynthesis, RNA regulation, energy metabolism, and cell division during infection with members of seven distinct clades of lytic p…

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