Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM/PM and is driven by the CC16 38GG genotype.

Last updated on 4-1-2023 by Sarah Nauwelaerts

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Particular matter (PM) exposure is a big hazard for public health, especially for children. Serum CC16 is a well-known biomarker of respiratory health. Urinary CC16 (U-CC16) can be a noninvasive alternative, albeit requiring adequate adjustment for renal handling. Moreover, the SNP CC16 G38A influences CC16 levels. This study aimed to monitor the effect of short-term PM exposure on CC16 levels, measured noninvasively in schoolchildren, using an integrative approach. We used a selection of urine and buccal DNA samples from 86 children stored in an existing biobank. Using a multiple reaction …

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