In vitro and in vivo infectious potential of coxiella burnetii: a study on Belgian livestock isolates.

Last updated on 22-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article



Q-fever is a zoonosis caused by the gram-negative obligate intracellular pathogen Coxiella burnetii. Since its discovery, and particularly following the recent outbreaks in the Netherlands, C. burnetii appeared as a clear public health concern. In the present study, the infectious potential displayed by goat and cattle isolates of C. burnetii was compared to a reference strain (Nine Mile) using both in vitro (human HeLa and bovine macrophage cells) and in vivo (BALB/c mice) models. The isolates had distant genomic profiles with one–the goat isolate–being identical to the predominant strai…

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