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Résultats de la recherche - 54 results

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

epoxide-bearing analogs ATX- II, ATX- III, and STTX- III show the highest cytotoxic, genotoxic, and mutagenic potential in vitro. Under hormone-sensitive conditions, AOH and AME act as moderate xenoestrogens, but ...

Reduced humoral immune response after BNT162b2 coronavirus disease 2019 messenger RNA vaccination in cancer patients under antineoplastic treatment.

chemotherapy, immunotherapy, targeted or hormonal therapy, and patients with a hematologic malignancy receiving rituximab or after allogeneic hematopoietic stem cell transplantation. Vaccine safety and efficacy ...

Iron Deficiency Is a Risk Factor for Thyroid Dysfunction During Pregnancy: A Population-Based Study in Belgium

Volume 31, Issue 12 (2021) Abstract: Background: Iron deficiency affects thyroid hormone synthesis by impairing the activity of the heme-dependent thyroid peroxidase. The prevalence of iron deficiency is ...

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

Main targets for toxicity are neurodevelopment, the liver, thyroid hormone homeostasis and the reproductive and immune systems. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour ...

Variability of iodine concentrations in the human placenta.

Issue 1 (2020) Abstract: Iodine is an essential trace element, necessary for the production of thyroid hormones, which play a key role in optimal foetal growth and (neuro-) development. To date, iodine ...

Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population: an ENVIRONAGE cohort study

Translational Medicine, Volume 18, Issue 1 (2020) Abstract: Background Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal ...

Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays

with our hormonal system by binding to endocrine receptors, resulting in adverse health effects such as reproductive damage, developmental impairment, obesity, diabetes and cancers. The aim of this study ...

Falsification of biotechnology drugs: current dangers and/or future disasters?

traditional doping related substances and image-enhancing polypeptides (e.g., human growth hormone, melanotan II) also essential medicines such as insulin, oxytocin and monoclonal antibodies have been ...

Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.

irrespective of tumor stage. The pooled risk of endometrial cancer among women with PMB was 9% (95% CI, 8%-11%), with estimates varying by use of hormone therapy (range, 7% [95% CI, 6%-9%] to 12% [95% CI, ...

Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women

women with PMB was 9% (95% CI, 8%-11%), with estimates varying by use of hormone therapy (range, 7% [95% CI, 6%-9%] to 12% [95% CI, 9%-15%]; P <.001 for heterogeneity) and geographic region (range, 5% ...

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