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Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.
1 and Th17 responses in mice in an OVA immunisation model, and that further analysis of their potential as novel adjuvants for subunit vaccines is warranted. Health Topics: Health and disease monitoring ...
Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for development of adjuvants for subunit vaccines
identifying the receptor involved in the recognition of several PAMP s. Furthermore, we showed that the activation of this receptor by these mycolate esters triggers the induction of protective Th1 and Th17 ...
Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity
a proximal cis cyclopropane elicited antigen-specific Th1 and cytotoxic T-cell immune responses, whereas intratracheal immunization elicited pulmonary Th17 responses. These immune stimulatory activities ...
Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis
circulating TFR compared with healthy control subjects. Furthermore, the circulating TFR compartment of MS patients displayed an increased proportion of Th17-like TFR. Finally, TFR of MS patients had a strongly ...
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells.
Interferon Regulatory Factors Interleukin-12 Interleukin-17 Intestinal Mucosa Macrophages mice Mice, Transgenic Monocytes Phagocytes Phenotype Receptors, CCR2 T-Lymphocyte Subsets Th17 Cells Abstract: The ...
M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.
Mutation Mycobacterium bovis Mycobacterium tuberculosis Mycolic Acids Organ Specificity Oxygen Species Specificity Spleen Th1 Cells Th17 Cells Trachea Treatment Outcome Tuberculosis Vaccination virulence ...
Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine-treated, Mycobacterium bovis BCG-vaccinated mice36543
Cell cells challenge Context Cytokines Deficiency Down-Regulation electronic Enzyme-Linked Immunosorbent Assay Female Functional IL-17A im immune response Immunization immunology INFECTION ...
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.
abrogation of the infection-induced Th1 function — and even more so Th17 function — in the lungs. Treatment of WT mice with the LXR agonists TO901317 and GW3965 resulted in a 10-fold decrease of the pulmonary ...