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Résultats de la recherche - 16 results
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
However, transcriptional analyses can be a powerful tool as well. Analyses on susceptible strains provide information on the response to the stress a drug is causing, showing which mechanisms are activated ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
sensitive and resistant strains can yield additional information, like the activation of specific efflux pumps. However, due to the high cost of RNA seq analyses, genome wide transcriptional analyses of drug ...
FabR regulates Salmonella biofilm formation via its direct target FabB.
Escherichia coli Proteins Fatty Acid Synthase, Type II Fatty Acids, Unsaturated Gene Expression Regulation, Bacterial Promoter Regions, Genetic Regulon Salmonella typhimurium Transcription Factors Abstract: ...
Development of giant bacteriophage phiKZ is independent of the host transcription apparatus
and late promoters. Unique to varphiKZ is its ability to complete its infection in the absence of bacterial RNA polymerase (RNAP) enzyme activity. We propose that transcription of the varphiKZ genome is ...
Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans
Tuberculosis Universities university use vaccine Abstract: Recent results with respect to the secretory production of bio-active Mycobacterium tuberculosis proteins in Streptomyces have stimulated the further ...
Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect.
Transcriptional Activation Abstract: Recently the environmental obesogen hypothesis has been formulated, proposing a role for endocrine disrupting compounds (EDC s) in the development of obesity. To evaluate this ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
SENSITIVITY series stability Stereoisomerism Structure-Activity Relationship study Tuberculosis work Abstract: Mycobacterial transcriptional repressor EthR controls the expression of EthA, the bacterial ...
Synthetic EthR inhibitors boost antituberculous activity of ethionamide36849
ethionamide, are activated by the mycobacterial monooxygenase EthA, the production of which is controlled by the transcriptional repressor EthR. Here we identify drug-like inhibitors of EthR that boost the ...
Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells4408
Biochem.Biophys.Res.Commun., Volume 320, Issue 2, Number 324, p.318- 324 (2004) Keywords: 0 a Activation Amino Acid Sequence Animals article Belgium Carrier Proteins Cell Cell Line cells chemistry Combination Context Cyclic AMP ...
Insect basic leucine zipper proteins and their role in cyclic AMP-dependent regulation of gene expression4404
Activation or inhibition of this pathway will ultimately affect the transcriptional regulation of various genes through distinct responsive sites. In vertebrates, the best- characterized nuclear targets of PKA ...