Résultats de la recherche - 121 results

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...

A Benchmark Dose-based strategy for evaluating the combined effects of genotoxic compounds

Belgium (2023) Keywords: benchmark dose modelling genotoxicity mixtures Health Topics:  Food consumption and food safety Consommation et sécurité alimentaires Voedselconsumptie en –veiligheid Service:  ...

Towards Characterization and genotoxicity assessment of mycotoxin mixtures present in food.

Mertens Source: BelTox Annual Meeting, Brussels, Belgium (2023) Keywords: additivity benchmark dose modelling genotoxicity mixtures Mycotoxins Health Topics:  Food consumption and food safety Consommation ...

The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects)

Source: Joint 3R Symposium 2023 (2023) Keywords: genotoxicity NAMs transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des ...

An AOP-based IATA to pave the way toward animal-free genotoxicity testing

Publication Type: Scientific poster, presentation or proceeding Authors: Birgit Mertens Source: Joint 3R Symposium 2023, Brussels, Belgium (2023) Keywords: adverse outcome pathways genotoxicity ...

Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals

Source: 57th Congress of the European Societies of Toxicology (Eurotox 2023), Ljubljana, Slovenia (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health ...

Mixtures of genotoxicants: does the principle of additivity apply?

Belgium (2023) Keywords: additivity benchmark dose modelling genotoxicity mixtures Mycotoxins Health Topics:  Food consumption and food safety Consommation et sécurité alimentaires Voedselconsumptie en ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

methodologies (NAM s) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics ...

Mixtures of genotoxicants: does the principle of additivity apply?

Keywords: additivity benchmark dose modelling genotoxicity mixtures Mycotoxins Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de ...

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