Characterization of suspected dermal fillers containing hyaluronic acid
Efficacité et sécurité des vaccins, médicaments et produits de santé - Qualité des laboratoires médicaux
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Résumé:
Hyaluronic acid (HA) has important applications in the field of orthopedics, ophthalmology and cosmetics. This polymer can be present in cosmetic products or can be used as a dermal filler. The latter frequently contains cross-linked HA. Today's methods to quantify the amount of cross-linked HA are not very specific. In this paper the development and validation of a specific identification and quantification method is described. The proposed method utilizes an essential pre-extraction step prior to identification by infra-red spectroscopy followed by an identity confirmation and quantif…