Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage20
Public Access
Published
Auteurs
Merker,M. [2]; Blin,C. [3]; Mona,S. [4]; Duforet-Frebourg,N. [5]; Lecher,S. [6]; Willery,E. [7]; Blum,M.G. [8]; Rusch-Gerdes,S. [9]; Mokrousov,I. [10]; Aleksic,E. [11]; Allix-Beguec,C. [12]; Antierens,A. [13]; Augustynowicz-Kopec,E. [14]; Ballif,M. [15]; Barletta,F. [16]; Beck,H.P. [17]; Barry,C.E.,III [18]; Bonnet,M. [19]; Borroni,E. [20]; Campos-Herrero,I. [21]; D M. Cirillo [22]; Cox,H. [23]; Crowe,S. [24]; Crudu,V. [25]; Diel,R. [26]; Drobniewski,F. [27]; M. Fauville [28]; Gagneux,S. [29]; Ghebremichael,S. [30]; Hanekom,M. [31]; S Hoffner [32]; Jiao,W.W. [33]; Kalon,S. [34]; Kohl,T.A. [35]; Kontsevaya,I. [36]; Lillebaek,T. [37]; Maeda,S. [38]; V Nikolayevskyy [39]; Rasmussen,M. [40]; Rastogi,N. [41]; Samper,S. [42]; Sanchez-Padilla,E. [43]; Savic,B. [44]; Shamputa,I.C. [45]; Shen,A. [46]; Sng,L.H. [47]; Stakenas,P. [48]; Toit,K. [49]; Varaine,F. [50]; Vukovic,D. [51]; Wahl,C. [52]; R. Warren [53]; Supply,P. [54]; Niemann,S. [55]; Wirth,T. [56]Mots-clés
Résumé:
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years…