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Résultats de la recherche - 75 results
Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.
quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
methodologies (NAM s) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics ...
Effects of long-term exposure to 50 Hz magnetic fields on cell viability, genetic damage, and sensitivity to mutagen-induced damage.
damage induced by known mutagens. At certain time points, statistically significant difference in genotoxicity test results were observed between the MF-exposed cells and the control cells. However, these ...
Impact of experimental design factors on the potency of genotoxicants in in vitro test
Abstract: Previous studies have shown that differences in experimental design factors may alter the potency of genotoxic compounds in in vitro genotoxicity tests. Most of these studies used traditional ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells
(NAM s) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics DNA ...
In Silico Methods for Chromosome Damage.
Keywords: Chromosome Aberrations Chromosomes DNA Damage Humans Mutagenicity Tests Mutagens Mutation Abstract: Due to the link with serious adverse health effects, genotoxicity is an important toxicological ...
Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers.
solvent-assisted flavor evaporation (SAFE) technique coupled to GC- MS (SIM) was developed and validated. Focus was put on authorized flavoring substances requiring specific attention due to a genotoxic concern ...
Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers
Alcohol-free beers Flavoring substances GC–MS genotoxicity SAFE Abstract: The regulatory landscape of flavorings is evolving, thereby putting pressure on control laboratories to develop analytical methods for ...
Development of a “Freeze-Pour” Sample Preparation Method for the GC Analysis of Semivolatile Flavouring Chemicals Present in E-cigarette Refill Liquids
Volume 34, Issue 6, Number 230 (2021) Keywords: e-cigarettes flavours GC-MS genotoxicity Abstract: During the past decade, e-cigarettes have become increasingly popular. To guarantee their safe use and to ...
Safety assessment of titanium dioxide (E171) as a food additive.
With respect to genotoxicity, the Panel concluded that TiO particles have the potential to induce DNA strand breaks and chromosomal damage, but not gene mutations. No clear correlation was observed ...