Résultats de la recherche - 11 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: A candidate gene approach was used to identify mutations as associated with ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

insufficient to support the use of WGS as an alternative to conventional phenotype-based DST, due to mutation catalogue limitations.  Here we present a new tool,, which provides the same functionality based on ...

Strong increase of true and false positive mycobacterial cultures sent to the National Reference Centre in Belgium, 2007 to 2016.

observational study investigated the numbers of analyses at the NRC and false positive cultures (interpreted as containing mycobacteria at referring clinical laboratories, but with no mycobacterial DNA detected ...

Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study.

assays in tuberculosis (TB) laboratory diagnosis requires effective management of time and resources. OBJECTIVE: To further develop and assess at multiple centres a time-and-motion (T&M) tool as an ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

Volume 22, Issue 1 (2018) Keywords: Carbapenems repurposed drugs XDR-TB Abstract: BACKGROUND: Extensively drug-resistant tuberculosis (XDR- TB), defined as TB caused by a Mycobacterium strain resistant to ...

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection

lungs, spleen and liver and mycobacteria specific spleen cell IFN-γ, IL-10 and IL-17 production as well as serum antibody responses were analyzed. Isolates varied in virulence, with human and porcine ...

Molecular epidemiology of Mycobacterium tuberculosis complex in Brussels, 2010-2013.

Surveillance Tuberculosis Tuberculosis, Multidrug-Resistant Urban Health Young adult Abstract: The tuberculosis (TB) incidence rate in Brussels-Capital Region is 3-fold higher than in Belgium as a whole. Eight ...

MALDI-TOF for the identification of Mycobacteria and their drug resistance profiles

desorption ionization-time of flight mass spectrometry (MALDI- TOF MS) has been increasingly introduced as a valuable method for the identification of bacteria and yeast1. This technique, which generates mass ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

recent report of the WHO ranks tuberculosis (TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

(TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising (480 000 new cases), impeding the ...

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