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Résultats de la recherche - 4 results

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.

The 2.2 Å crystal structure reveals that this novel homo-dimeric protein has no identifiable structural homologues. Our biochemical data indicate that acidic patches on the convex outer surface bind RN ...

Experimental approaches to identify small RNAs and their diverse roles in bacteria- what we have learnt in one decade of MicA research5238

function, (iii) structural analysis. The complex mechanisms of action of MicA deliver some original insights in the sRNA field which includes the existence of dimer formation or simultaneous cis and trans ...

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

preintegration complex to the chromatin through a direct interaction with integrase (IN). Small molecules that bind the LEDGF /p75 binding pocket of the HIV IN dimer (LEDGIN s) block HIV replication through ...

Viral interference of the bacterial RNA metabolism machinery.

this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack 2 conserved RNA binding sites on the scaffold ...

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