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Résultats de la recherche - 9 results
First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin.
to be present in a Tn125 transposon integrated on a plasmid. CONCLUSIONS: The discovery of this extensively-drug resistant A. baumannii strain carrying bla in Benin is worrying, especially because of ...
Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid
incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...
Commentary on the MID3 Good Practices Paper.
Model-Informed Drug Discovery and Development (MID3) group in promoting greater consistency in practice, application, and documentation of M&S and considers the paper is an important contribution towards ...
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
Viral Drug Discovery Foot-and-Mouth Disease Models, Theoretical Oximes Ribavirin RNA, Viral Sulfonamides Virus Cultivation Virus Replication Abstract: Foot-and-mouth disease virus (FMDV) is a highly ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Design DRUG Drug Design drug effects Drug Synergism electronic Ethionamide EVALUATION exposure expression France Human im IS journal Macrophages metabolism mice microbiology Microsomes,Liver ...
Experimental tuberculosis in the Wistar rat: a model for protective immunity and control of infection36574
properties together with the ease of manipulation, relatively low cost and well established use of rats in toxicology and pharmacokinetic analyses make the rat a good animal model for TB drug discovery ...
Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.
binding studies on intact plated cells. LINKED ARTICLES: This article is part of a themed section on Analytical Receptor Pharmacology in Drug Discovery. To view the other articles in this section visit ...
Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid
counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains to ...
Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid.
incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...