Résultats de la recherche - 35 results

Chemical and toxciological characterization of e-liquid cigarettes

quantitative in silico models. In total, potential genotoxicity activity was predicted for 44 flavourings. Based on information from European databases, genotoxicity could be confirmed for five of these ...

Use of Whole Genome Sequencing Data for a First in Silico Specificity Evaluation of the RT-qPCR Assays Used for SARS-CoV-2 Detection.

were developed in January 2020 for initial in silico specificity evaluation and to verify whether the targeted loci are highly conserved. Now that more whole genome data have become available, we used ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

Hermans, Nina; Foubert, Kenn Source: Food and Chemical Toxicology (2019) Keywords: antigenotoxicity Erythrina latissima In vivo antihepatotoxic activity Leguminosae Prenylated flavonoids Abstract: Stem bark ...

Development of a sample preparation method for the GC-analysis of e-cigarette refill liquids

flavourings diacetyl and acetylpropionyl. The low and semi-volatiles contain potential genotoxic flavourings, selected through in-silico genotoxicity screening of 436 identified components in 77 e-liquid ...

Genotoxic evaluation of the liquids present in electronic cigarettes

performed with flavouring substances that have previously been identified in e-liquids. First, the genotoxic potential of these compounds was assessed using in silico prediction software Derek and Sarah ...

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.

safety. By combining in silico predictions with existing in vitro and in vivo genotoxicity data from publicly available literature sources and results from in vitro gene mutation experiments, the 106 study ...

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

glycosyltransferase genes. This observation spurred the development of an in silico workflow which extracts the Shigella serotype from Next-Generation Sequencing (NGS) data, taking into account gene functionality. Both ...

Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills

cancer. Therefore, in this study, a prioritization strategy based on a combination of analytical screening, in silico prediction and literature consultation was developed for identifying potentially ...

Application of whole genome data for in silico evaluation of primers and probes routinely employed for the detection of viral species by RT-qPCR using dengue virus as a case study.

immense amount of available sequence data renders this however a labour-intensive and complex task. RESULTS: We present a bioinformatics approach that enables in silico evaluation of primers and probes ...

RE-Place: centralizing information on alternative methods to animal testing to promote knowledge sharing

Publication Type: Scientific poster, presentation or proceeding Authors: Van Mulders, Mieke Source: EUROTOX, Brussels, Belgium (2018) Keywords: 3R alternative methods Database in chemico In silico ...

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