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Résultats de la recherche - 25 results

Batch release of vaccines in Europe: from method transfer to first commercial batch available on the market. Straightforward approach that requires a proactive mindset of the manufacturer.

product specifications or on relevant batch record data (which are usually supplied in section 3 of the protocol). Important modifications of the manufacturing and testing procedures, changes in reagents ...

Motif switches: decision-making in cell regulation.

interactions. These interactions underlie the ability of proteins to make decisions by combining regulatory information encoded in a protein’s expression level, localisation and modification state. This raises ...

Guidelines for Independent Lot Release of Vaccines by Regulatory Authorities

requirements, or modifications may be justified and made by a national regulatory authority. It is recommended that modifications to the principles and technical specifications of these guidelines be made only on ...

Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients88

Toxicology treatment Volume Abstract: Because the sepsis-induced pharmacokinetic (PK) modifications need to be considered in aminoglycoside dosing, the present study aimed to develop a population PK model for ...

New techniques of genetic modification and the GMO definition

146, Brussels, p.144- 146 (2010) Keywords: a AS at biosafety Biotechnology challenge Context definition European European Union Genetic genetic modification genetically Genetically modified Genetically ...

Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 24386

potency than EM-2 which confirmed the usefulness of structural modifications in obtaining new leads for pain-relief therapeutics Service:  Quality of laboratories Kwaliteit van laboratoria Qualité des ...

Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4

mechanism to regulate inflammation. In this study, we describe modification of the CXC chemokine stromal cell-derived factor 1alpha/ CXCL12 by peptidylarginine deiminase (PAD) that converts arginine residues ...

Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure4392

the mu-opioid receptor and thus represent a potential framework for modification into mu-antagonists. Here we report on the synthesis and biological evaluation of novel [d-2-Nal(4)]endomorphin-2 ...

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.

eosinophil-rich airway inflammation, airway hyperreactivity and airway wall modifications known as remodelling. We previously demonstrated that the spores of two allergenic moulds, Alternaria alternata and ...

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