Résultats de la recherche - 19 results
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.
protease that mediates the activation of several innate and adaptive immune cells in response to multiple receptors, and therapeutic MALT1 targeting is believed to be a valid approach for autoimmunity and ...
Multivalent binding of herpesvirus to living cells is tightly regulated during infection.
8 (2018) Abstract: Viral infection, initiated by the landing of a virion on a cellular surface, is largely defined by the preliminary interactions established between viral particles and their receptors at ...
Activity-Based Detection and Bioanalytical Confirmation of a Fatal Carfentanil Intoxication.
a fatality in Norway. Blood, urine and vitreous, obtained during autopsy, were screened with a newly developed opioid activity reporter assay able to detect compounds based on their μ-opioid receptor activity ...
Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.
health Public-health Receptor response Responses result results Service Species strain structure study sugar Synthetic System TDM Term Tuberculosis vaccine vaccines WIV-ISP Abstract: The cell wall of ...
Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for development of adjuvants for subunit vaccines
Rather, the nature of the sugar and the number of acyl chains bound to it seem to dictate the affinity of the glycolipid for Mincle receptor in vitro. In vivo, we observed that TDM, TMM and GMM induce ...
PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes.
C-epsilon rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Transduction, Genetic Abstract: A critical role has been assigned to protein kinase C (PKC)ε in the control of intracellular calcium ...
Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays.
Tumor Endocrine disruptors Genes, Reporter Humans Infant Equipment mice Polycarboxylate Cement Receptors, Cytoplasmic and Nuclear Abstract: Endocrine activity of 65 compounds migrating from polycarbonate ...
DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer.
Analysis Pancreatic Neoplasms Prognosis Receptor, Notch1 Receptor, Notch3 Abstract: BACKGROUND: There is an increasing interest for Notch signalling pathway and particularly Delta-like ligand 4 (DLL4) as ...
Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines.
Transduction Tuberculosis Vaccines Vaccines, Subunit Abstract: INTRODUCTION: Pathogen recognition receptors (PRR s) recognize pathogen-associated molecular patterns, triggering the induction of inflammatory ...
Endocrine activity of mycotoxins and mycotoxin mixtures.
Receptors, Androgen Receptors, Estrogen Receptors, Thyroid Hormone Abstract: Reporter gene assays incorporating nuclear receptors (estrogen, androgen, thyroid β and PPAR γ2) have been implemented to assess the ...