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Résultats de la recherche - 19 results
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.
efficiently identify pollutants of interest. The evidence will be integrated in novel Adverse Outcome Pathways to facilitate regulatory acceptance of non-animal methods for cardiotoxicity testing. The current ...
EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects
indications for genotoxicity were obtained. Finally, no formation of smaller particles following colonic fermentation of NC was observed. For the integration of these results in regulatory hazard assessment of ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Publication Type: Scientific poster, presentation or proceeding Authors: Sivakumar Murugadoss; Alexandra Schaffert; Ronette Gehring; Tom Roos; Nunzia Linzalone; Gabriele Donzelli; Martin Paparella; Birgit Mertens Source: 57th Congress of the European Soci ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Publication Type: Scientific poster, presentation or proceeding Authors: Sivakumar Murugadoss; Alexandra Schaffert; Ronette Gehring; Tom Roos; Nunzia Linzalone; Gabriele Donzelli; Martin Paparella; Birgit Mertens Source: Joint 3R Symposium, Brussels, Belg ...
Oncolytic Viruses: An Inventory of Shedding Data from Clinical Trials and Elements for the Environmental Risk Assessment.
assessment of subject safety, quality and efficacy aspects of medicinal products for human use, genetically modified viruses are also governed by EU regulatory frameworks requiring an environmental risk ...
A Systematic Review on Pollutant Induced Cardiotoxicity: Providing a Toxicological Foundation for NAM Development and Regulatory Acceptance
Publication Type: Scientific poster, presentation or proceeding Authors: T. Roos; C. Leenaars; A. Schaffert; M. Paparella; S. Murugadoss; Birgit Mertens; N. Linzalone; G. Donzelli; M. Ritskes-Hoitinga; R. Gehring Source: 12th World Congress on Alternative ...
Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs.
Publication Type: Peer reviewed scientific article Authors: Alexandra Schaffert; Sivakumar Murugadoss *; Birgit Mertens *; Martin Paparella Source: Volume 40, Issue 2 (2023) Keywords: Cardiotoxicity environmental exposure Hazardous Substances Humans Healt ...
Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs.
Publication Type: Peer reviewed scientific article Authors: Schaffert, Alexandra; Murugadoss, Sivakumar; Mertens, Birgit; Paparella, Martin Source: ALTEX, Volume 40, Issue 2 (2023) Keywords: Cardiotoxicity environmental exposure Hazardous Substances Human ...
In Silico Methods for Chromosome Damage.
endpoint in each regulatory setting with respect to human health, including for pharmaceuticals. To this extent, a compound potential to induce gene mutations as well as chromosome damage needs to be ...
The purity of tattoo inks, screening substances of high concern
Publication Type: Peer reviewed scientific article Authors: Bart Desmedt; Melissa Vanhamme; Eric Deconinck Source: Regulatory Toxicology and Pharmacology, Volume 129 (2022) Keywords: Ink Primary ...