Vouliez-vous dire
events

Résultats de la recherche - 40 results

Clustering of Tadalafil API Samples According to their Manufacturer in the Context of API Falsification Detection

falsified samples. In total, 46 tadalafil API samples from 13 different manufacturers were collected. For all samples fingerprint data was collected through analysis of impurities and residual solvents, mass ...

Development of a reliable UHPLC-MS/MS method for simultaneous determination of zearalenone and zearalenone-14-glucoside in various feed products

in water as the loading solution, 50% methanol in water as the washing solvent, and 5 ml of methanol as the elution solvent yielded the optimal purification efficiencies. The established method was ...

Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers.

solvent-assisted flavor evaporation (SAFE) technique coupled to GC- MS (SIM) was developed and validated. Focus was put on authorized flavoring substances requiring specific attention due to a genotoxic concern ...

GEONs API fingerprint project: Selection of analytical techniques for clustering of sildenafil citrate API samples

chromatography for residual solvents, X-ray diffraction and Nuclear Magnetic Resonance (NMR) spectroscopy. Chemometrics applied to the collected data showed that all manufacturers could be discriminated based on ...

European fingerprint study on omeprazole drug substances using a multi analytical approach and chemometrics as a tool for the discrimination of manufacturing sources

analysis carried out by 7 European laboratories on 28 samples from 11 manufacturers with 5 analytical techniques (related substances with HPLC, residual solvents with GC- MS, near infrared spectroscopy, ...

Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers

a wide range of compounds in various types of food and drinks. In order to improve the monitoring of flavoring substances, a versatile and accurate analytical method using the solvent-assisted flavor ...

All in one method for the analysis of multiclass food additives using UHPLC-MS/MS

in Europe. A QuEChERS based extraction has been devised using acidified acetonitrile as extraction solvent, followed by a C18 and PSA dispersive solid phase extraction step. For the development of the ...

Residual solvents in pharmaceutical substances and products

Publication Type: Scientific book or chapter Authors: Eric Deconinck; Bart Desmedt Source: Residual solvents in pharmaceutical substances and products, Elsevier, Volume 2, Issue 1201, Toronto, ...

Impurity profiling of the most frequently encountered falsified polypeptide drugs on the Belgian market

API-related impurities, small molecule contaminants (defined as organic small molecules not belonging to the other categories), elemental impurities and residual solvents. This comprehensive study showed that ...

Antimutagenicity, antioxidant activity and cytotoxicity of n-tetracosanol, eiocosanoic acid and arjunolic acid isolated from Combretum microphyllum (Combretaceae)

using Salmonella typhimurium TA98. TA100 and TA102.Solvent-solvent fractionation was used to partition the extracts and following theprinciple of bioassay-guided fractionation, three compounds were ...

QR code

QR code for this page URL