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Résultats de la recherche - 9 results

A Transcriptomic Biomarker to Classify Chemical-Induced Histone Deacetylase Inhibition in Human HepaRGTM Cells

Science Forum, Ottawa, Canada (2024) Keywords: HepaRG cells histone deacetylase inhibition transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu ...

The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects)

Source: Joint 3R Symposium 2023 (2023) Keywords: genotoxicity NAMs transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des ...

Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals

Source: 57th Congress of the European Societies of Toxicology (Eurotox 2023), Ljubljana, Slovenia (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

Issue 2 (2023) Keywords: Algorithms Animals Biomarkers DNA Damage Gene Expression Profiling Humans Supervised Machine Learning Abstract: Transcriptomics-based biomarkers are promising new approach ...

The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRGTM cells

Source: EEMGS meeting, Malaga, Spain (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid ...

The GENOMARK biomarker inhuman HepaRGTM cells: a new approach methodology for genotoxicity assessment

SaferWorldByDesign webinar, Online (2023) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de ...

GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry

International cosmetic congress, Antalya, Turkey (2022) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation ...

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

approaches, we have developed an upgraded, innovative, and proprietary gene classifier. This gene classifier is based on transcriptomic changes induced by 12 genotoxic and 12 non-genotoxic reference compounds ...

In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.

Alessandra; Milushev, Dimiter; Benfenati, Emilio; Rogiers, Vera; Doktorova, Tatyana Y Source: Mutagenesis, Volume 31, Number 461, p.453-61 (2016) Keywords: Cosmetics In silico Mutagenicity Tests Transcriptomics ...

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