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Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

picornaviral polyprotein is essential for viral replication. Therefore, viral proteases are attractive targets for anti-viral therapy. Most assays available for testing proteolytical activity of proteases are ...

Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.

Outbreaks Europe Female Reassortant Viruses RNA, Viral Serotyping Sheep, Domestic Vaccines, Subunit Viral Vaccines Virus Replication Abstract: Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have ...

Proteomic characterization of murid herpesvirus 4 extracellular virions.

Virion Abstract: Gammaherpesvirinae, such as the human Epstein-Barr virus (EBV) and the Kaposi’s sarcoma associated herpesvirus (KSHV) are highly prevalent pathogens that have been associated with several ...

An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle.

CD8-Positive T-Lymphocytes Gammaherpesvirinae Gene Expression Regulation, Viral Genome, Viral Lymphoproliferative Disorders Malignant Catarrh Plasmids Rabbits Virus Latency Virus Replication Abstract: ...

Different replication profiles in specific-pathogen-free chickens of two H7 low pathogenic avian influenza viruses isolated from wild birds.

Pathogen-Free Organisms Time Factors Virus Replication Abstract: During an active wild bird survey conducted in Belgium from 2007 to 2011, two low pathogenic avian influenza (LPAI) H7 viruses were isolated from ...

Impact of a novel inactivated PRRS virus vaccine on virus replication and virus-induced pathology in fetal implantation sites and fetuses upon challenge.

reproductive syndrome virus Pregnancy Pregnancy Complications, Infectious Sus scrofa Swine Vaccination Vaccines, Inactivated Viral Vaccines Viremia Abstract: Preventing congenital infection is important for the ...

Antibody evasion by a gammaherpesvirus O-glycan shield.

Sequence Alignment Viral Envelope Proteins Virion Virus Replication Abstract: All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often ...

Capsid proteins from field strains of foot-and-mouth disease virus confer a pathogenic phenotype in cattle on an attenuated, cell-culture-adapted virus

Volume 92, Issue 5, Number 1151 (2011) Abstract: Chimeric foot-and-mouth disease viruses (FMDV s) have been generated from plasmids containing full-length FMDV cDNAs and characterized. The parental virus ...

Susceptibility of in vitro produced hatched bovine blastocysts to infection with bluetongue virus serotype 8.

10(4.9) TCID50 of the virus resulted in active viral replication in between 25 and 100% of the cells at 72 h post exposure. The infected blastocysts also showed growth arrest as evidenced by lower total ...

Classical swine fever: comparison of oronasal immunisation with CP7E2alf marker and C-strain vaccines in domestic pigs.

Immunosorbent Assay Palatine Tonsil Swine Vaccination Vaccines, Synthetic Viral Vaccines Virus Replication Abstract: Effective oronasal vaccination against classical swine fever (CSF) is essential to achieve ...

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