Résultats de la recherche - 93 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

to achieving rapid, universal drug susceptibility testing for complex (MTBC). We aimed to generate a WHO endorsed catalogue of mutations to serve as a global standard for interpreting molecular ...

Retrospective evaluation of routine whole genome sequencing of Mycobacterium tuberculosis at the Belgian National Reference Center, 2019.

MTB strains analyzed in 2019 (n = 306). RESULTS: In all cases, the WGS-based procedure was able to identify correctly the MTB species. Compared to MGIT drug susceptibility testing (DST), the sensitivity ...

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

Source: Eur Respir J (2020) Abstract: Conventional molecular tests for detecting complex (MTBC) drug resistance on clinical samples cover a limited set of mutations. Whole genome sequencing (WGS) typically ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

Volume 4 (2019) Abstract: Two billion people are infected with, leading to 10 million new cases of active tuberculosis and 1.5 million deaths annually. Universal access to drug susceptibility testing (DST) ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

phenotypic Drug Susceptibility Testing (DST) of M. tuberculosis (Mtb), multiple DNA-based methods were successfully introduced over the last years. Although these are fast and sensitive, they (a) are based on ...

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

Source: New England Journal of MedicineNew England Journal of MedicineN Engl J Med (2018) ISBN: 0028-4793 Abstract: BACKGROUND: The World Health Organization recommends drug-susceptibility testing of ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

Pieter-Jan Ceyssens Source: 39th Annual Congress of the European Society of Mycobacteriology, Issue ESM, Dresden, Germany (2018) Keywords: drug susceptibility testing Mycobacterium tuberculosis Health Topics:  ...

MALDI-TOF for the identification of Mycobacteria and their drug resistance profiles

Society of Mycobacteriology, ESM, Catania, Sicily, Italy (2016) Keywords: drug susceptibility testing identification MALDI-TOF Mycobacterium tuberculosis Abstract: In the last years, matrix-assisted laser ...

Case report of a false positive result of the Xpert(®) MTB/RIF assay for rifampicin resistance in Mycobacterium tuberculosis complex.

positive for TB and positive for RIF resistance. Confirmatory molecular tests and the phenotypic drug susceptibility determination supported the diagnosis of TB but not RIF resistance. The patient was ...

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