Résultats de la recherche - 30 results

MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.

as a scaffold protein for NF-κB signalling and a cysteine protease that cleaves substrates, further promoting the expression of immunoregulatory genes. Deregulated MALT1 activity has been associated ...

Scalable chromatography-based purification of virus-like particle carrier for epitope based influenza A vaccine produced in Escherichia coli.

diagnostic tools, and gene therapy vectors. Size, oligomer assembly and repetitiveness of epitopes are optimal features to induce strong immune responses. Several VLP-based vaccines are currently licensed and ...

Engineering nucleases for gene targeting: safety and regulatory considerations.

(2014) Keywords: Deoxyribonucleases Gene Targeting Genetic Therapy Humans SAFETY Abstract: Nuclease-based gene targeting (NBGT) represents a significant breakthrough in targeted genome editing since it is ...

Biosafety of Gene Therapy Vectors Derived From Herpes Simplex Virus Type 14581

Publication Type: Peer reviewed scientific article Authors: Lim,F.; Khalique,H.; Ventosa,M.; Aline Baldo Source: Current Gene Therapy, Volume 13, Issue 6, Number 491, p.478- 491 (2013) ISBN: ...

General considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination.

introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health ...

Biosafety of viral vectors commonly used in gene therapy and vaccination.

Publication Type: Peer reviewed scientific article Authors: Philippe Herman Source: Curr Gene Ther, Volume 13, Issue 6, p.383-4 (2013) Keywords: Genetic Therapy Genetic Vectors Hazardous Substances ...

Environmental risk assessment of clinical trials involving modified vaccinia virus Ankara (MVA)-based vectors.

strain, which has been developed as a vaccine against smallpox, is since the nineties widely tested in clinical trials as recombinant vector for vaccination or gene therapy applications. Although MVA is ...

Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.

lead to the emergence/selection of resistant variants hampering further treatment. Therefore, it was the purpose of this study to investigate the intra-host variation of the RdRp gene, targeted by ...

Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination.

Clinical Trials as Topic Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Mammals Neoplasms Poxviridae Infections Practice Guidelines as Topic Vaccination vaccinia virus Viral Vaccines ...

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