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General considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination.

introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health ...

Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.

lead to the emergence/selection of resistant variants hampering further treatment. Therefore, it was the purpose of this study to investigate the intra-host variation of the RdRp gene, targeted by ...

Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination.

Clinical Trials as Topic Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Mammals Neoplasms Poxviridae Infections Practice Guidelines as Topic Vaccination vaccinia virus Viral Vaccines ...

Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus

Hermans,K.; Lavigne,R. Source: PLoS One, Volume 6, Issue 9, p.e24418 (2011) Keywords: Antibiotic resistance phage phage therapy Staphylococcus aureus Abstract: The increasing antibiotic resistance in bacterial ...

Contained use of bacteriophages: Risk assessment and biosafety recommendations

antibodies application applications AS assessment bacteria Bacteriophages biosafety Biotechnology containment Control delivery Dna DNA vaccines environment Evaluating Evolution gene gene therapy gene transfer ...

Contained use of Bacteriophages: Risk assessment and biosafety recommendations2463

environment epub Evaluating Evolution factors Field gene gene therapy gene transfer general Genetic Genome genomic health Human human health implement Laboratories lysis management measure measures medical ...

CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation.

for the exon 11 (1199G>A), 21 (3435C>T) and 26 (2677G>T/A) polymorphisms in the ABCB1 gene and for the intron 3 polymorphism in the CYP3A5 gene. Tac blood and PBMC concentrations were ...

State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

transfer vehicles, as used for both research and gene therapy applications, because of their stable integration in non-dividing and dividing cells and long-term transgene expression. Along with our ...

Modulating mouse innate immunity to RNA viruses by expressing the Bos taurus Mx system.

1 (boMx1) is endowed with exceptional anti-rabies-virus activity. This finding has prompted us to seek an appropriate in vivo model for confirming and evaluating gene therapy strategies. Using a BAC ...

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