Résultats de la recherche - 60 results

A Transcriptomic Biomarker to Classify Chemical-Induced Histone Deacetylase Inhibition in Human HepaRGTM Cells

Publication Type: Scientific poster, presentation or proceeding Authors: Julie Buick; Eunnara Cho; Anouck Thienpont; Birgit Mertens; Andrew Williams; Carole Yauk; Matthew Meier Source: Health Canada ...

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake

(IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé Risico- en gezondheidsimpactevaluatie Risk and ...

Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals

Source: 57th Congress of the European Societies of Toxicology (Eurotox 2023), Ljubljana, Slovenia (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health ...

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake

Birgit Mertens Source: Joint 3R Symposium, Brussels, Belgium (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment (IATA) pollutants Health Topics:  ...

Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity Assessment

testing and assessment (IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé Risico- en ...

A Systematic Review on Pollutant Induced Cardiotoxicity: Providing a Toxicological Foundation for NAM Development and Regulatory Acceptance

Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé Risico- en gezondheidsimpactevaluatie Risk and health ...

Mixtures of genotoxicants: does the principle of additivity apply?

Keywords: additivity benchmark dose modelling genotoxicity mixtures Mycotoxins Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de ...

The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRGTM cells

Source: EEMGS meeting, Malaga, Spain (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid ...

Development of an AOP-based IATA for genotoxicity

Integrated approaches to testing and assessment (IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé ...

The GENOMARK biomarker inhuman HepaRGTM cells: a new approach methodology for genotoxicity assessment

SaferWorldByDesign webinar, Online (2023) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de ...

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