Résultats de la recherche - 26 results

Pyrogen testing of phage therapeutic products

is pivotal to limit the risk of non-endotoxin contamination. These pyrogens can be detected by the monocyte activation test (MAT), which employs human blood cells to quantify pyrogenicity in vitro. In ...

Validation of an animal-free analytical method for the detection of bacterial endotoxins in human vaccines

assays are suitable for all vaccines tested, although the most appropriate technique of endotoxins quantification depends on the type of vaccine. Health Topics:  Effectiveness and safety of vaccines, ...

Characterization of a Bacteriophage GEC_vB_Bfr_UZM3 Active against.

Infections Bacteriophages Bacteroides fragilis Humans Abstract: is a commensal gut bacterium that is associated with a number of blood and tissue infections. It has not yet been recognized as one of the ...

Controlled Human Infection Studies: Proposals for guidance on how to design, develop and produce a challenge strain.

was discussed in the presentation dedicated to “routine manufacturing”. Health Topics:  Effectiveness and safety of vaccines, medicines and health products- Quality of medical laboratories Efficacité et ...

Development of a multiplex immunoassay for simultaneous detection of antigens in DTaP vaccines

Virtual (2021) Keywords: 3R Vaccine Potency Abstract: Routine batch quality testing before vaccine release, notably for potency evaluation, still relies on animal use for several animal and human vaccines. ...

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

establish a screening strategy to prioritize the flavouring substances of highest concern for human health. In the present study, a prioritization strategy combining analytical screening, in silico tools and ...

Use of Whole Genome Sequencing Data for a First in Silico Specificity Evaluation of the RT-qPCR Assays Used for SARS-CoV-2 Detection.

Keersmaecker Source: Int J Mol Sci, Volume 21, Issue 15 (2020) Keywords: Betacoronavirus Coronavirus Infections Databases, Genetic Genome, Viral Humans Open Reading Frames Pandemics Pneumonia, Viral ...

Human challenge trial workshop: Focus on quality requirements for challenge agents, Langen, Germany, October 22, 2019.

Keywords: Biological Products Drug Development Human Experimentation Humans vaccines whole genome sequencing Abstract: Controlled human infection models can be helpful to study pathogenesis and immune ...

Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills

prioritize the substances of highest concern for human health. In this context, genotoxicity is a key (toxicological) endpoint as it is related to a broad range of adverse human health effects including ...

Zona pellucida gene mRNA expression in human oocytes is related to oocyte maturity, zona inner layer retardance and fertilization competence.

ANSWER: The ZP mRNA expression in human oocytes is related to oocyte maturity, zona inner layer (IL) retardance and fertilization capacity. WHAT IS KNOWN ALREADY: ZP structure and birefringence provide ...

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