Résultats de la recherche - 301 results

In silico methods for chromosome damage

aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data without the need for test material, several in silico tools for chromosome damage have been ...

Het RE-Place project focust op het bevorderen van alternatieve methoden die dierproeven kunnen helpen vervangen

Europees niveau immers veel vooruitgang geboekt in de ontwikkeling van proefdiervrije methoden. Onderzoekers maken onder andere gebruik van menselijk materiaal in cel- en weefselculturen (in vitro), of van ...

Flanders and Brussels join forces to tackle animal testing

and institutions. This includes using human material in cell and tissue cultures (in vitro), or computer models (in silico). “These new, innovative techniques play a very important role in answering questions that ...

Strategy to Develop and Evaluate a Multiplex RT-ddPCR in Response to SARS-CoV-2 Genomic Evolution.

continuously evolving worldwide. In the present study, we proposed a methodology based on an in silico and in vitro analysis. First, we used all information offered by available whole-genome sequencing data for ...

The bacteriophage LUZ24 "Igy" peptide inhibits the Pseudomonas DNA gyrase.

in vitro gyrase activity and interacts with the P. aeruginosa GyrB subunit, possibly by DNA mimicry, as indicated by a de novo model of the peptide and mutagenesis. In vivo, overproduction of Igy blocks DNA ...

Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative Diphenpipenol.

Piperazines Abstract: In this paper, the identification and full characterization of a novel non-fentanyl opioid sourced online, which is a member of the 1-substituted-4-(1,2-diphenylethyl)piperazine ...

Safety assessment of titanium dioxide (E171) as a food additive

between the physico-chemical properties of TiO2 particles and the outcome of either in vitro or in vivo genotoxicity assays. A concern for genotoxicity of TiO2 particles that may be present in E 171 could ...

Assessment of hazards and risks associated with dietary exposure to mineral oil for the Belgian population

scenarios, a health concern related to MOAH exposure could not be excluded, highlighting that more data are needed to perform an adequate risk assessment. The possibility to use in vitro bioassays to collect ...

Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide

the development of alternative testing strategies such as computational (predictive) models based on in vitro testing. However, the variations in in vitro experimental conditions can influence the ...

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

transhexanal, there was a clear concern for in vivo genotoxicity. A selection of 4 out of the remaining 22 flavourings was tested in two in vitro genotoxicity assays. Three out of the four tested flavourings ...

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