Résultats de la recherche - 261 results

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  ...

Rational arguments for regulatory acceptance of consistency testing: benefits of non-animal testing over release testing of vaccines.

techniques to measure critical quality attributes. However, introduction of in vitro alternatives to replace in vivo release assays of authorized vaccines is challenging. AREAS COVERED: This report describes ...

Development of a Droplet Digital PCR to Monitor SARS-CoV-2 Omicron Variant BA.2 in Wastewater Samples

used as a complementary method to other SARS-CoV-2 surveillance systems. It allows the emergence and spread of infections and SARS-CoV-2 variants to be monitored in time and place. This study presents an ...

P20-10: Microcystin-LR and aflatoxin M1 contamination in dairy milk samples and their combined in vitro hepatotoxicity

Publication Type: Peer reviewed scientific article Authors: Mohamed F. Abdallah; Van Camp, C.; Recote, J. May; Wannes Van Hassel *; Julien Masquelier *; A. Rajkovic Source: Toxicology Letters, Volume 384 (2023) Health Topics:  Food consumption and food sa ...

The consistency approach for the substitution of in vivo testing for the quality control of established vaccines: practical considerations and progressive vision

Publication Type: Peer reviewed scientific article Authors: L. Tesolin; J.-F. Dierick; Wim Van Molle Source: Open Research Europe (2022) Keywords: human vaccines in vitro testing in vivo testing ...

Impact of experimental design factors on the potency of genotoxicants in in vitro test

Abstract: Previous studies have shown that differences in experimental design factors may alter the potency of genotoxic compounds in in vitro genotoxicity tests. Most of these studies used traditional ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells

shift towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Service:  Évaluation des risques et de l'impact sur la santé Risico- en ...

In Silico Methods for Chromosome Damage.

addressed. For chromosome damage, i.e., the induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data ...

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