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The consistency approach for the substitution of in vivo testing for the quality control of established vaccines: practical considerations and progressive vision

Publication Type: Peer reviewed scientific article Authors: L. Tesolin; J.-F. Dierick; Wim Van Molle Source: Open Research Europe (2022) Keywords: human vaccines in vitro testing in vivo testing ...

Implementation over the past 20 years of the 3R's principle for batch release at the Scientific Institute of Public Health, Belgium (IPH).

in vivo studies by a reliable in vitro assay omitting the use of laboratory animals, but this is an even more time consuming effort. Health Topics:  Vaccine batch conformity Vaccin lot conformiteit ...

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