Résultats de la recherche - 67 results
Guidelines for Independent Lot Release of Vaccines by Regulatory Authorities
requirements, or modifications may be justified and made by a national regulatory authority. It is recommended that modifications to the principles and technical specifications of these guidelines be made only on ...
Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients88
Toxicology treatment Volume Abstract: Because the sepsis-induced pharmacokinetic (PK) modifications need to be considered in aminoglycoside dosing, the present study aimed to develop a population PK model for ...
New techniques of genetic modification and the GMO definition
146, Brussels, p.144- 146 (2010) Keywords: a AS at biosafety Biotechnology challenge Context definition European European Union Genetic genetic modification genetically Genetically modified Genetically ...
Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 24386
potency than EM-2 which confirmed the usefulness of structural modifications in obtaining new leads for pain-relief therapeutics Service: Quality of laboratories Kwaliteit van laboratoria Qualité des ...
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4
mechanism to regulate inflammation. In this study, we describe modification of the CXC chemokine stromal cell-derived factor 1alpha/ CXCL12 by peptidylarginine deiminase (PAD) that converts arginine residues ...
Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure4392
the mu-opioid receptor and thus represent a potential framework for modification into mu-antagonists. Here we report on the synthesis and biological evaluation of novel [d-2-Nal(4)]endomorphin-2 ...
Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
eosinophil-rich airway inflammation, airway hyperreactivity and airway wall modifications known as remodelling. We previously demonstrated that the spores of two allergenic moulds, Alternaria alternata and ...
Animal cell cultures: Risk Assessment and biosafety recommendations
EVALUATION general genetic modification hazard health Human human health IS LEVEL measure measures ON ORIGIN pathogen pathogenic recommendation Recommendations Reduction Research result risk Risk Assessment ...
Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code.
Publication Type: Peer reviewed scientific article Authors: Merimi, Makram; Klener, Pavel; Szynal, Maud; Cleuter, Yvette; Pierre Kerkhofs; Burny, Arsène; Martiat, Philippe; Van den Broeke, Anne Source: J Virol, Volume 81, Issue 11, p.5929-39 (2007) Keywor ...
Cell-mediated LDL oxidation: the impact of transition metals and transferrin103
metal-catalysed oxidative modifications, especially in the presence of copper. By binding metals, Tf was able to strongly impair this process. In conclusion, by generating oxygen radicals, activated U937 cells were ...