Résultats de la recherche - 187 results

PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment.

provide access to a targeted drug for patients whose tumors harbor actionable mutations in case the matched drug is not available through reimbursement or clinical trials in Belgium. Health Topics:  Cancer ...

Whole-Genome Sequence Approach and Phylogenomic Stratification Improve the Association Analysis of Mutations With Patient Data in Influenza Surveillance.

mainly focused on the hemagglutinin gene. Whole-genome sequencing (WGS) enables tracking mutations across all influenza segments allowing a better understanding of the epidemiological effects of intra- and ...

In Silico Methods for Chromosome Damage.

Keywords: Chromosome Aberrations Chromosomes DNA Damage Humans Mutagenicity Tests Mutagens Mutation Abstract: Due to the link with serious adverse health effects, genotoxicity is an important toxicological ...

An alarming high prevalence of resistance-associated mutations to macrolides and fluoroquinolones in Mycoplasma genitalium in Belgium: results from samples collected between 2015 and 2018ObjectivesMethodsResultsConclusion

Publication Type: Peer reviewed scientific article Authors: Irith De Baetselier; Chris Kenyon; Wim Vanden Berghe; Hilde Smet; Kristien Wouters; Dorien Van den Bossche; Vuylsteke, Bea; Tania Crucitti Source: Sexually Transmitted Infections, Volume 97, Issu ...

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

Walker; CRyPTIC Consortium; Seq&Treat Consortium; Derrick W Crook; Nazir Ismail; Timothy C Rodwell; Vanessa Mathys Source: Lancet Microbe, Volume 3, Issue 4 (2022) Keywords: Drug Resistance mutations ...

In silico methods for chromosome damage

to human health, including for pharmaceuticals. To this extent, a compound’s potential to induce gene mutations as well as chromosome damage needs to be addressed. For chromosome damage, i.e. the ...

Strategy and Performance Evaluation of Low-Frequency Variant Calling for SARS-CoV-2 Using Targeted Deep Illumina Sequencing

of mutations present at low abundances using the mutations defining the SARS-CoV-2 lineage B.1.1.7 (alpha variant) as a case study. Real sequencing data were in silico modified by introducing mutations ...

Strategy to Develop and Evaluate a Multiplex RT-ddPCR in Response to SARS-CoV-2 Genomic Evolution.

and reliable diagnostic testing to prevent and control the viral transmission. However, inaccurate results may occur due to false negatives (FN) caused by polymorphisms or point mutations related to the ...

Large diversity of linezolid-resistant isolates discovered in food-producing animals through linezolid selective monitoring in Belgium in 2019.

period. The presence of LR chromosomal mutations, transferable LR genes and their genetic organizations and other resistance genes, as well as LR isolate relatedness (from this study and the NCBI database) ...

Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.

infection were age >40 years, at least one F508 del mutation and pancreatic insufficiency.Overall, 23.7% of pwCF were admitted to hospital, 2.5% of those to intensive care, and regretfully 11 (1.4%) died. ...

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