Résultats de la recherche - 7 results
Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills
investigated in silico with two complementary (quantitative) structure-activity relationship ((Q) SAR) models (Derek Nexus, Sarah Nexus). In total, 57 flavouring components were identified with a structural ...
Performance of in silico models for mutagenicity prediction of food contact materials
these predictions, the capacity of the prediction models to generate (sufficiently) reliable results for a particular type of compounds needs to be evaluated. In the current study, performance parameters to predict ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non- FCM ...
Zona pellucida gene mRNA expression in human oocytes is related to oocyte maturity, zona inner layer retardance and fertilization competence.
ANSWER: The ZP mRNA expression in human oocytes is related to oocyte maturity, zona inner layer (IL) retardance and fertilization capacity. WHAT IS KNOWN ALREADY: ZP structure and birefringence provide ...
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.
based on the combination of multiple (quantitative) structure-activity relationship ((Q) SAR) tools. Non-evaluated substances used in printed paper and board food contact materials (FCM) were selected for ...
Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability.
76, p.74-8 (2016) Keywords: Administration, Cutaneous Animals Biological Availability Consumer Product Safety Cosmetics Dose-Response Relationship, Drug Humans Models, Molecular Molecular Structure ...
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
moieties. This work was done using a combination of structure-based drug design and in vitro/ex vivo evaluations of ethionamide boosters on the targeted protein EthR and on the human pathogen Mycobacterium ...