Age-Dependent Differences in Pseudorabies Virus Neuropathogenesis and Associated Cytokine Expression.

Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)

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The severity of clinical symptoms induced by pseudorabies virus (PRV) infection of its natural host is inversely related to the age of the pig. During this study, 2- and 15-week-old pigs were inoculated with PRV strain NIA3. This resulted in important clinical disease, although the associated morbidity and mortality were lower in older pigs. Quantitative PCR analysis of viral DNA in different organs confirmed the general knowledge on PRV pathogenesis. Several new findings and potential explanations for the observed age-dependent differences in virulence, however, were determined from the st…

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