Anti-TNF-alpha therapy does not ameliorate disease in a model of acute virus-endotoxin mediated respiratory disease in pigs36852

Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)

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Peer reviewed scientific article


Tumour necrosis factor-alpha (TNF-alpha) has been shown to play a role in many inflammatory conditions. Currently anti-TNF-alpha drugs (e.g. etanercept) are used in humans for treatment of autoimmune diseases. In this study we aimed to elucidate the role of TNF-alpha in the development of virus-endotoxin-induced respiratory disease. Twenty-two caesarean derived colostrum deprived pigs were used. Initially, the availability in the lungs and circulation, and possible clinical and inflammatory effects of etanercept alone were assessed in 4 pigs after intratracheal and intraperitoneal administr…

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