Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)
Peer reviewed scientific article
AuteursP. Lefevre; Peirs,P.; Braibant,M.; M. Fauville; R. Vanhoof; K Huygen; Wang,X.M.; Pogell,B.; Wang,Y.; Fischer,P.; Metz,P.; Content,J.
OBJECTIVES: Early studies have indicated that pamamycins, a group of macrodiolides first isolated from Streptomyces alboniger, have potent antimicrobial activity against Gram-positive bacteria, fungi and mycobacteria but not against Gram-negative bacteria. The recent availability of highly purified and reasonable quantities of several pamamycins through their total syntheses has rendered possible more extensive studies on their effects on mycobacteria. METHODS: Bioluminescent strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium smegmatis, expressing the luxA and …