Development and validation of a HS/GC-MS method for the simultaneous analysis of diacetyl and acetylpropionyl in electronic cigarette refills

Last updated on 12-6-2020 by Jill Alexandre

Peer reviewed scientific article




The use of e-cigarettes as alternative for tobacco cigarettes has become increasingly popular, even though their safety has not yet been scientifically established. One of the frequently raised concerns is the potential toxicity of certain flavours present in the e-liquids, such as diacetyl and acetylpropionyl. It is therefore important to be able to identify and quantify both compounds. Numerous analytical methods have been published for determining e-liquid compositions, but concerns exist with respect to the lack of analytical evaluation. Hence in this study, a new HS/GC-MS-based method …

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