TY - Generic T1 - Biosafety risk assessment of the Severe Acute Respiratory Syndrome (SARS) coronavirus and containment measures for the diagnostic and research laboratories Y1 - 2004 A1 - Philippe Herman A1 - Verlinden,Y. A1 - Didier Breyer A1 - Van Cleemput,E. A1 - Bernard Brochier A1 - Myriam Sneyers A1 - Snacken,R. A1 - Hermans,P. A1 - Pierre Kerkhofs A1 - Liesnard,C. A1 - Rombaut,B. A1 - Marc Van Ranst A1 - van der Groen,G. A1 - Goubau,P. A1 - William Moens KW - Activity KW - Africa KW - ALL KW - an KW - AS KW - assessment KW - at KW - Belgium KW - biosafety KW - Case KW - containment KW - Control KW - Coronavirus KW - Countries KW - disease KW - environment KW - Europe KW - Guidelines KW - health KW - Human KW - INFECTION KW - International KW - investigation KW - IS KW - Laboratories KW - LEVEL KW - levels KW - measure KW - measures KW - ON KW - Order KW - organization KW - POPULATION KW - Practice KW - PRACTICES KW - production KW - recommendation KW - Recommendations KW - Research KW - Respiratory KW - response KW - risk KW - Risk Assessment KW - SAFETY KW - SARS KW - SBB KW - Spread KW - use KW - VIRUS KW - WHO KW - work KW - world KW - World Health Organization AB - At the end of 2002, an outbreak of a new viral respiratory illness, called SARS (Severe Acute Respiratory Syndrome virus) occurred in China. The disease spread over Asia, North America, Europe and Africa. In response to the SARS outbreak, the World Health Organization (WHO) coordinated an international collaboration that included clinical, epidemiologic and laboratory investigations, and initiated efforts to control the spread of SARS. As in other countries it has been decided to establish biosafety guidelines and recommendations in Belgium with particular emphasis on handling clinical specimens associated with SARS for research, production and clinical laboratories. Taking into account that there is so far no SARS case reported in Belgium as well as in other countries in the world, and based on a scientific risk assessment related to the contained use of biological agents, the SARS-CoV was classified as a Risk Group 3 agent. In relation to the reported biosafety assessment, the SARS-CoV should be handled in appropriate biosafety containment levels in order to avoid laboratory acquired infections and spread of the disease in the human population and the environment. Therefore, diagnostic activities with inactivated clinical specimens associated with SARS cases and specimens originating from countries where SARS is documented but not associated with SARS cases, should be performed under Biosafety Level 2 (BSL-2) conditions. Diagnostic activities involving non-inactivated clinical specimens associated with SARS should be carried out under BSL-2 containment with BSL-3 safety equipment and work practices. Culture of SARS-CoV and all research activities involving SARS-CoV require a BSL-3 containment JF - Appl.Biosaf. VL - 9 CP - 3 U1 - 360 ER -