TY - JOUR T1 - Aspergillus tubingensis: a major filamentous fungus found in the airways of patients with lung disease JF - Med.Mycol. Y1 - 2016 A1 - Gautier,M. A1 - A-C Normand A1 - L'ollivier,C. A1 - C Cassagne A1 - Reynaud-Gaubert,M. A1 - Dubus,J.C. A1 - Bregeon,F. A1 - Marijke Hendrickx A1 - Gomez,C. A1 - Ranque,S. A1 - Piarroux,R. KW - a KW - acute KW - Adult KW - airway KW - Amphotericin B KW - article KW - AS KW - Aspergillus KW - at KW - BCCM/IHEM KW - Belgium KW - Brussels KW - Case KW - chronic KW - Clinical KW - Clinical samples KW - Context KW - Cystic Fibrosis KW - de KW - disease KW - Diseases KW - electronic KW - Establish KW - Failure KW - Features KW - Fibrosis KW - filamentous fungi KW - France KW - Fungi KW - Group KW - health KW - Human KW - identify KW - im KW - INFECTION KW - Institute KW - IS KW - Itraconazole KW - journal KW - Laboratories KW - Less KW - Lung KW - Mass KW - Mass Spectrometry KW - method KW - Mycology KW - Nose KW - p KW - parasitology KW - Patient KW - patients KW - pattern KW - pediatric KW - period KW - public KW - public health KW - Public-health KW - Pulmonary KW - Respiratory KW - Respiratory disease KW - respiratory diseases KW - Role KW - Sample KW - Samples KW - SB - IM KW - Service KW - Species KW - study KW - Technique KW - TESTING KW - time KW - time of flight KW - Type KW - Universities KW - university AB - The black Aspergillus group comprises A. niger and 18 other species, which are morphologically indistinguishable. Among this species subset, A. tubingensis, described in less than 30 human cases before 2014, is primarily isolated from ear, nose, and throat samples. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has emerged as a powerful technique to identify microbes in diagnostic settings. We applied this method to identify 1,720 filamentous fungi routinely isolated from clinical samples our laboratory over a two-year study period. Accordingly, we found 85 isolates of A. niger, 58 of A. tubingensis, and six other black Aspergillus (4 A. carbonarius and 2 A. japonicus). A. tubingensis was the fifth most frequent mold isolated in our mycology laboratory, primarily isolated from respiratory samples (40/58 isolates). In this study, we mainly aimed to describe the clinical pattern of Aspergillus tubingensisWe analyzed the clinical features of the patients in whom A. tubingensis had been isolated from 40 respiratory samples. Thirty patients suffered from cystic fibrosis, chronic obstructive pulmonary disease or other types of chronic respiratory failure. Strikingly, 20 patients were experiencing respiratory acute exacerbation at the time the sample was collected. Antifungal susceptibility testing of 36 A. tubingensis isolates showed lower amphotericin B MICs (P < 10(-4)) and higher itraconazole and voriconazole MICs (P < 10(-4) and P = .0331, respectively) compared with 36 A. niger isolates. Further studies are required to better establish the role that this fungus plays in human diseases, especially in the context of cystic fibrosis and chronic pulmonary diseases VL - 54 CP - 5 U1 - 39292 M3 - http://dx.doi.org/10.1093/mmy/myv118 ER -