TY - JOUR T1 - Development and validation of a HS/GC-MS method for the simultaneous analysis of diacetyl and acetylpropionyl in electronic cigarette refills JF - J.Pharm.Biomed.Anal. Y1 - 2017 A1 - Sophia Barhdadi A1 - Michael Canfyn A1 - Patricia Courselle A1 - Rogiers,V. A1 - Vanhaecke,T. A1 - Eric Deconinck KW - Analyses KW - analysi KW - analysis KW - approach KW - AS KW - Belgium KW - bias KW - Brussels KW - Control KW - Development KW - electronic KW - EVALUATION KW - food KW - health KW - identify KW - Institute KW - IS KW - journal KW - measurement KW - Medicine KW - method KW - methodology KW - methods KW - ON KW - profile KW - public KW - public health KW - Public-health KW - Quality KW - Quality Control KW - Quantification KW - SAFETY KW - Sample KW - Samples KW - SCREENING KW - study KW - tobacco KW - toxicity KW - Toxicology KW - use KW - VALIDATION AB -

The use of e-cigarettes as alternative for tobacco cigarettes has become increasingly popular, even though their safety has not yet been scientifically established. One of the frequently raised concerns is the potential toxicity of certain flavours present in the e-liquids, such as diacetyl and acetylpropionyl. It is therefore important to be able to identify and quantify both compounds. Numerous analytical methods have been published for determining e-liquid compositions, but concerns exist with respect to the lack of analytical evaluation. Hence in this study, a new HS/GC-MS-based method was developed for the screening and quantification of diacetyl and acetylpropionyl in e-liquids. This method was fully validated using the 'total error' approach. The LOQ of the analytical method was 5ppm for diacetyl and acetylpropionyl. The obtained accuracy profiles show that the beta-expectation tolerance intervals did not exceed the acceptance limits of+/-10%, meaning that 95% of future measurements will be included in the [-10%, 10%] bias limits. As proof of applicability, the validated method was successfully applied on a small set of e-liquid samples, indicating that this methodology could be used for routine quality control analyses of e-liquids

VL - 142 U1 - 2682 M3 - S0731-7085(16)31467-4 [pii];10.1016/j.jpba.2017.04.050 [doi] ER -