TY - JOUR T1 - Cervical cytology biobanking in Europe. JF - Int J Biol Markers Y1 - 2010 A1 - M. Arbyn A1 - Evert-Ben Van Veen A1 - Andersson, Kristin A1 - Bogers, Johannes A1 - Boulet, Gaƫlle A1 - Bergeron, Christine A1 - von Knebel-Doeberitz, Magnus A1 - Dillner, Joakim KW - Alphapapillomavirus KW - Biological Specimen Banks KW - Cervix Uteri KW - Dna KW - Europe KW - Female KW - Guidelines as Topic KW - Humans KW - Medical Record Linkage KW - Molecular Diagnostic Techniques KW - Papanicolaou Test KW - Papillomavirus Infections KW - Papillomavirus Vaccines KW - REGISTRIES KW - Rna KW - specimen handling KW - Terminology as Topic KW - Uterine Cervical Neoplasms KW - Uterine Cervicitis KW - Vaginal Smears AB -

A cervical cytology biobank (CCB) is an extension of current cytopathology laboratory practice consisting in the systematic storage of Pap smears or liquid-based cytology samples from women participating in cervical cancer screening with the explicit purpose to facilitate future scientific research and quality audit of preventive services. A CCB should use an internationally agreed uniform cytology terminology, be integrated in a national or regional screening registry, and be linked to other registries (histology, cancer, vaccination). Legal and ethical principles concerning personal integrity and data safety must be respected strictly. Biobank-based studies require approval of ethical review boards. A CCB is an almost inexhaustible resource for fundamental and applied biological research. In particular, it can contribute to answering questions on the natural history of HPV infection and HPV-induced lesions and cancers, screening effectiveness, exploration of new biomarkers, and surveillance of the short- and long-term effects of the introduction of HPV vaccination. To understand the limitations of CCB, more studies are needed on the quality of samples in relation to sample type, storage procedures, and duration of storage.

VL - 25 CP - 3 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20872354?dopt=Abstract ER -