TY - JOUR T1 - Phytochemical analysis, antioxidant, anticoagulant and in vitro toxicity and genotoxicity testing of methanolic and juice extracts of Beta vulgaris L. JF - South African Journal of Botany Y1 - 2019 A1 - Edziri, H. A1 - R. Jaziri A1 - O. Haddad A1 - R. Anthonissen A1 - Aouni, M. A1 - Mastouri, M. A1 - Luc Verschaeve KW - Alkaline comet assay KW - Anticoagulant activity KW - Beta vulgaris KW - Juice KW - Methanolic extract KW - Vitotox test AB -

Beet root (Beta vulgaris L.) is well known in cuisine and is also used in traditional medicine to prevent many diseases. We investigated the methanolic extract and juice with respect to the phenolic and flavonoid contents and evaluated their antioxidant, anticoagulant and genotoxic activities. Genotoxicity was studied with the bacterial Vitotox test and the alkaline comet assay involving human C3A liver cells. The methanolic extract had the highest phenolic and flavonoid contents with values of 39.75 mg GAE/g and 20.73 mg CE/g extract, respectively. Methanolic extract and juice showed surprising anticoagulant and antioxidant activities. They were devoid of any genotoxicity or cytotoxic effects. The results show the potential of the plant, especially the juice, as a new source of bioactive molecules for therapeutic purposes, possibly in the treatment of cardiovascular diseases.

VL - 126 M3 - 10.1016/j.sajb.2019.01.017 ER -