TY - JOUR T1 - Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization. JF - J Infect Dis Y1 - 2021 A1 - Cornelis A De Pijper A1 - Annefleur C Langedijk A1 - Sanne Terryn A1 - Steven Van Gucht A1 - Martin P Grobusch A1 - Abraham Goorhuis A1 - Cornelis Stijnis KW - Rabies KW - Vaccination AB -

BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.

METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.

RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen.

CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.

M3 - 10.1093/infdis/jiab034 ER -